Recidivující chronické infekce močových cest (RIMC) - stará diagnóza a nová fakta

Quantitative CEST with BIRDS

D. Coman, G. Kiefer, D. L. Rothman, D. A. Sherry, and F. Hyder Diagnostic Radiology, Yale University, New Haven, CT, United States, Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States, Macrocyclics, Dallas, TX, United States, Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States, Advanced Imaging Resear...

A novel class of polymeric pH-responsive MRI CEST agents.

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially "off" when the polymers form micelles near physiological pH but is activated to the "on" state when the micelles dissociate in an...

Cest / Wiener Neustadt Bioelectrochemistry and More

Pressure Dependent Signal Enhancement in Hyper-CEST

Introduction The so called hyper-CEST method promises tremendous potential on molecule-specific MR imaging using hyperpolarized Xe caged in functionalized cryptophane cages [1]. It was shown that these biosensors can be utilized as highly sensitive temperature probes [2] and that molecule-specific signals in the lower nM regime can be detected when experimental parameters are optimized to yield...

Tumor-specific expression and detection of a CEST reporter gene.

PURPOSE To develop an imaging tool that enables the detection of malignant tissue with enhanced specificity using the exquisite spatial resolution of MRI. METHODS Two mammalian gene expression vectors were created for the expression of the lysine-rich protein (LRP) under the control of the cytomegalovirus (CMV) promoter and the progression elevated gene-3 promoter (PEG-3 promoter) for constit...